Callisto Protocol Bosses + Fight Guide

A Definitive Guide that discusses all the Bosses that appear in Callisto Protocol and how to defeat them.

Callisto Protocol Bosses Cover Image
Detailed talk about Bosses in Callisto Protocol

In-game bosses are your enemies, usually appearing at the end of a mission or chapter. Callisto Protocol includes two boss fights, which is insultingly low for a game around 16 hours long.

In this guide, we will discuss all these Bosses and how to defeat them to reach the end of the Callisto Protocol.

Key Takeaways

  • Callisto Protocol includes Two Bosses that are seen toward the end of the game.
  • These Bosses develop different attacking techniques that need to be countered.
  • Two Head appears multiple times throughout the campaign with similar attacking moves.
  • Captain Ferris shows up a couple of times in the final chapter.

These Bosses will show up later in the game when you gain enough experience to face them. Let’s dive right into the topic.

The Two Head

two head at Chapter 6 ending on the platform
First look at the Two Head in Chapter 6

Two Head is the first boss in Callisto Protocol that you face. The twin-headed monster will make its first appearance at the end of the 6th Chapter – Lost, then in the Colony, and finally in the Final Chapter, Tower.

To minimize damage:

  1. Dodge Extended Attacks: Avoid taking damage by dodging the extended hands of the Two Head boss.

As you continue dodging and dealing damage, Two Head enters its second phase, where one head separates the other from its limbs, resulting in a gruesome and brutal appearance. In this phase, the brute’s right arm wields a hammer, while the left arm resembles a sharp object, akin to the tip of an axe.

Attacking Techniques By Two Head

The Two Head Brute follows a specific set of moves it keeps using throughout the battle. When the fight starts, the Brute is strong, so it will charge and land a powerful hit with either its left arm or right.

As Two Head moves to its next transformed phase, it gets more aggressive and attacks more frequently. The monster will remove half of its upper body and will be left with only one arm.

Attacking Strategies Against Two Head

  1. Aim for the Head: Whenever you encounter the Two Head enemy, aim for its head as it is a weak point. Headshots will deal more damage and help you defeat the enemy faster.

  2. Dodge and Counter: When the Two Head charges at you or swings its arm, use the dodge mechanic to evade its attacks. Dodge to the left or right to avoid getting hit. After successfully dodging, counterattack with your Stun Baton to deal damage.

  3. Keep Your Distance: If you’re on the Minimum Security difficulty level, consider keeping a safe distance from the Two Head enemy and using firearms to deal damage. High-damage weapons like the Skunk Gun and Revolver can be effective in taking down the enemy from afar.

Remember that patience and precise aiming are key to defeating the Two Head enemy. Take your time, stay vigilant, and make the most of your resources to overcome this formidable foe in Callisto Protocol.

Also Read: All Achievements in Callisto Protocol


You will fight Two Head toward the end of 6th chapter on the platform. After the cut scene, quickly look to your right toward the crates and gather as much ammo as possible before it attacks.

Two Head - The Platform
One on One with Two Head at The Platform

To finish your first objective, separate one head, stand at some distance, and use a high-damage weapon like Skunk Gun to do the job. In the second phase, keep dodging the aggressive Two Head punches and use weaponry to finish him.

Toward the end of the fight, when the Brute has taken enough damage to get down on its knees, use the Stunt Baton to finish him.


The Boss is once again seen inside the Colony when Dani is inside the memory of the colonists where you see discover their bodies. After the cut scene, including Jacob and Dani, Two Head will make its second appearance when it throws Dani into the wall.

Two Head - Colony
Two Head Brute appearing at the colony

This time there is a little twist; the Two Head Brute will spawn tiny monsters around itself which crawl toward you and bite.

  1. Use Shotguns on Small Creatures: When the Two Head Brute spawns smaller monsters that crawl toward you, it’s best to use shotguns to deal with them. Aim for their heads with a single shotgun blast to take them down efficiently, conserving your ammunition.

  2. Leverage the Environment: The Colony Boss area offers more space to maneuver compared to the Platform. Utilize the environment, including obstacles, to create distance between you and the Two Head Brute. Keep the sprint button pressed to stay agile (LB on Xbox, L1 on PS, and Shift on PC).

  3. Collect Health and Ammo: If you’re running low on health, keep an eye out for blue boxes scattered around the area. Stomp them to collect health points and potentially find additional gun ammo.

  4. Maintain Distance: As with the previous encounter, try to keep the Two Head Brute at a distance. Using shotguns from a safe range can be an effective strategy. When it approaches the room, be prepared to aim at its head for maximum damage.

  5. Two-Phase Fight: The Two Head Brute battle consists of two phases. In the first phase, focus on bringing it to its knees. Once it’s down, use the Stun Baton to attack until one head is separated from the body. In the second phase, the brute becomes more aggressive, so be ready to adapt while sticking to your established strategies.


Two Head appears for the last time in the 8th chapter of Callisto Protocol. You will face him inside the Medical Ward. To defeat the Boss again, use same techniques and strategies.

Two Head - Medical Ward
Jacob Lee vs Two Head in the Medical Ward

Keep in mind to keep the defense strong by dodging its attacks and using shotguns at some distance from the Two Head.

Captain Ferris – Alpha

Human Ferris
Ferris before getting infected

Captain Leon Ferris transforms from a human to a fully infected big zombie boss. He has several scenes with Jacob throughout the game, and Ferris mentions him as 521, the inmate number.

Capt. Ferris initially gets infected inside the control room when Jacob and Elias work together to find a way out of the Black Prison. There, Ferris plans to kill Jacob, but Jacob releases three infected humans on Ferris and claims that he died there.

Ferris returns at the start of the 5th chapter when he is mutated and releases Jacob and Elias into the storm, but he never sees them again for some time.

The Mutated Captain returns stronger during the 8th Chapter, where he is fully transformed and ready to end you. This will be the most stressful fight of this game, as the chances of winning the battle in under 4 to 5 tries are very tough. Let’s find out how to end Captain Ferris.

Attacking Techniques By Ferris

To defeat Captain Ferris in Callisto Protocol:

  1. Focus on precise timing and defensive moves.
  2. Avoid aggressive attacks during his punches.
  3. Prioritize defense over offense.
  4. Break his shield during the Alpha phase.
  5. Be prepared to dodge his ranged spit attack.
  6. Strike when he’s vulnerable.
  7. Stay patient and wait for openings.

Since you have reached this far, also check out this Inventory Guide for Callisto Protocol

Attacking Strategies Against Ferris

First Phase

captain ferris return
Mutated Captain Ferris

To effectively battle Captain Ferris in Callisto Protocol:

  1. Dodge his initial flurry of punches.
  2. Observe his pattern and attack after he finishes his combo.
  3. Hit him twice with the Stun Baton, then target his marked weak spot for extra damage.
  4. Use ranged weapons like the assault rifle to hit his head.
  5. Save ammunition for the later part of the fight.
  6. After the transformation, stay patient and keep attacking when there’s an opening.
  7. Be prepared for a long and challenging battle in the second phase.

Keep an eye on your health and resources throughout the fight to ensure you’re adequately prepared.

Second Phase

gigantic zombie ferris
Ferris after his final transformation

In the second phase of the fight against Captain Ferris in Callisto Protocol:

  1. Utilize the larger room and stay in corners for cover.
  2. Collect health from stations and throw explosive objects from the room’s edges.
  3. Time your explosive throws to hit Ferris when he gets closer.
  4. Keep shooting his shield bubble with an assault rifle.
  5. Watch out for Ferris calling crawling monsters for assistance.
  6. Use a shotgun to deal with the crawling minions; aim for their heads.
  7. Dodge Ferris’s attacks and avoid his ranged spitting attack.
  8. Collect health and ammo drops from defeated crawling creatures.
  9. Continue shooting the shield bubble until a cutscene triggers to end the fight.


Bosses in Callisto Protocol are big monsters that look scary and ugly. You interact with your first boss toward the end of the 6th chapter on the platform. You can defeat them by saving as much ammo as you can and dodging their heavy attacks.

This is all for our guide. Visit our website to find more helpful guides on Callisto Protocol that can assist you in completing the story missions. Play Castillo Protocol on Xbox and PlayStation by buying the game from their respective stores. You can play it on PC through Steam.

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