Resident Evil 4 Remake Regenerators [All You Need To Know]

Resident Evil 4 Remake brings back the infamous Regenerators, and I'll tell you all you need to know about them and how to kill them.

Regenerators make a horrifying comeback in the Resident Evil 4 Remake and this time they’re even more hideous. They can extend their limbs, drawing Leon in close to bite with their sharp teeth.

Key Takeaways

  • Regenrators can also crawl on the ground at an amazingly fast pace after having one of their legs blown off.
  • To permanently take them down, players will have to use the Biosensor scope to identify and shoot the parasites residing with their bodies.
  • Their counterparts, the more horrifying Iron Maiden show up in Chap 14 and even further as a side quest for the Merchant titled “The Wandering Dead“.

RE4 Remake Regenerators

Regeneradors, also known as Regenerators, are far more deadly in the Resident Evil 4 Remake. The Regenerators in the remake have received significant enhancements, and while they were always terrifying due to their otherworldly appearance, their stride, and their capability to withstand countless dismemberments, they are now far more horrifying.

Hideous aren’t they? || Images by us: VeryAliGaming

In the remake, Regenerators exhibit faster movement, now able to lunge forward without legs, adding to their terrifying nature. Their elongated arms can be extended for grab attacks or, when close to Leon, transform into stinging spikes.

The updated graphics intensify the menace of Regenerators, showcasing enhanced damage capabilities. Two types exist: the standard Regenerators and the more formidable Iron Maidens with protruding spikes, which will be detailed further in the guide.

A significant challenge lies in the lack of explicit instructions on defeating them. Players must engage in trial and error to discover their weaknesses. Encountering them for the first time in the Abandoned Medical Facility during Chapter 13 may induce anxiety, but fear not; my guide will provide a comprehensive strategy for defeating them definitively.

How To Kill Regenerators

Save your ammo when dealing with Regenerators. They regrow limbs, so dismembering is ineffective. To defeat them, target the invisible parasites within their bodies using the Biosensor Scope to conserve ammo.

Images by us: VeryAliGaming

To acquire the Biosensor scope, players need the level 2 keycard from the Incubation Lab, which involves facing Regenerators without the scope, requiring substantial ammo. Once obtained, attach the scope to an assault rifle. Use the scope to locate and shoot the parasites within the Regenerators to eliminate them permanently. The parasites glow orange through the scope, and once all are eliminated, the Regenerators will explode and collapse.

Here are some tips we gathered that might help here:

  • Use shotguns and grenades to dismember them and slow them down
  • Using a knife is one approach to expose a Regenerator’s weak points. If you try to slice this monster from behind, it will produce a reddish glow if you strike an area close to a parasite.
  • Be careful; shooting their legs might stun them, but they will lunge at you even then.
Shoot the Glowy bits || Images by us: VeryAliGaming

Doing this will be required to obtain the Wrench Tool, which is essential to progress further in the story. Just fire at the pod to shatter the glass, eject the regenerator with the tool inside its body, and get ready to battle. Again, it is advised to stay as far away from these monsters as you can, so don’t shatter more pods than you have to unless you have a death wish. 

Iron Maiden Regenerators – Mutated 2nd Form

In the RE4 remake, Regenerators transform into the more terrifying Iron Maidens. Initially appearing dead, they resurrect as Iron Maidens, resembling Regenerators but with noticeable sharp spikes. Unlike before, they can shoot needles and pull in targets. Take cover instead of relying on distance to stay safe.

Those with needle phobias, be careful || Images by us: VeryAliGaming

In Chapter 14, prepare ample rifle ammo to face the Iron Maiden, similar to the standard Regenerator. Use the biosensor scope to target the parasites in their head if they transform. Aim for their weak points and stun them by shooting their head. Alternatively, remove their legs with a shotgun or grenade, then use the scope from a distance to finish them. Beware of their ability to use spikes even when grounded. When defeated, they explode violently, so take cover behind a corner.

The Wandering Dead Side Quest

In Resident Evil 4 Remake’s Chapter 14, a blue request mission called “The Wandering Dead” appears atop a box in the Cargo Depot’s second half, after Ashley smashes the depot wall. It mentions a strange wandering body needing elimination and directs to deal with a “strong threat” in the Incubation Lab. These threats resemble Regenerators but are more dangerous, inflicting serious damage with their spikes if approached closely.

Images by us: VeryAliGaming

To complete this quest, you’ll need to make your way to the Incubation Lab. Once there, multiple Regenerators are present, rather than killing them all (you can still do it if you wish), focus on the Spiked one. To make this fight as easy as possible, you’ll need a good supply of rifle ammunition, a fully tuned Stingray, and the Bio-Sensor Scope you discovered when you were in the surrounding areas earlier. 

Players can choose to attach the Biosensor Scope to either the Stingray, CQBR Assault Rifle, or even the LE-5 submachine gun. Unless you have the exclusive upgrade, the LE 5 lacks the penetrative power of a rifle but makes up for it with an extremely rapid rate of fire and is far more effective in close quarters. 

When you’ve finished the Wandering Dead task, turn it into the Merchant and get your x8 spinel reward.

Closing Remarks

That is everything you need to know about the Regenerators in Resident Evil 4 Remake. If you have other questions or need more help, don’t hesitate to post in the comment section below! You can also consider checking out other guides like the Blue Medallions guide and All Weapons List here. Thank you and see you at the next one!

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