A trailer was released yesterday, also revealing that the game will release in physical form.
It will also include reversible cover inserts and a full-color manual – somewhat of a rare commodity in this day and age.
It remains unclear whether or not the release will contain the original game, but the Repentance expansion alone will contain a large volume of content. The official website lists the following features:
A full alternate path with brand new chapters and a new final boss and ending
True cooperative play for up to 4 players
An impossible number of balance changes, visual and gameplay updates and fixes
130+ new items (700+ items in total)
Many new item combinations with logical effects, new visuals and mechanics
Two new playable characters
100+ new enemies, 25+ new bosses
7 new challenges, 5,000+ new room designs
You can pre-order The Binding of Isaac: Repentancehere (affiliate link).